Susan Ackerman

Susan Ackerman

UC San Diego
Biological Sciences

Ackerman Lab

Molecular mechanisms underlying neurodegeneration and CNS development

Ludmil Alexandrov

Ludmil Alexandrov

UC San Diego
Cellular and Molecular Medicine

Alexandrov Lab

Understanding the molecular processes that lead to cancer

Corina Antal

Corina Antal

UC San Diego
Pharmacology

Antal Lab

Understanding molecular mechanisms that drive cancer

Joan Heller Brown

Joan Heller Brown

UC San Diego
Pharmacology

Brown Lab

How G-protein signaling pathways regulate cell growth and inflammation and drive dysfunction in cancer and cardiac disease

Itay Budin

Itay Budin

UC San Diego
Chemistry and Biochemistry

Budin Lab

How lipids act to shape cells and their membrane-bound signaling networks

Xu Chen

Xu Chen

UC San Diego
Neuroscience

Chen Lab

Cellular and molecular mechanism underlying Alzheimer's disease and related neurodegeneration; Holistic regulation of neurodegeneration

Cosimo Commisso

Cosimo Commisso

Sanford Burnham Prebys

Commisso Lab

Signaling pathways that regulate metabolic stress tolerance in cancer

LeslieCrews

Leslie A. Crews

UC San Diego
Regenerative Medicine

Crews Lab

Cellular and Molecular signaling mechanisms that drive multiple myeloma stem cell activity and disease regeneration

Rich Daneman

Rich Daneman

UC San Diego
Pharmacology

Daneman Lab

Cellular and molecular mechanisms that regulate the blood-brain barrier in health and disease

Ed Dennis

Ed Dennis

UC San Diego
Pharmacology, Chemistry and Biochemistry

Dennis Lab

Mechanism of the Phospholipase A Superfamily in Initiating Lipid Cell Signaling in Inflammation

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Arshad Desai

UC San Diego
Biological Sciences

Desai Lab

Mechanisms ensuring accurate genome inheritance during cell division and their dysregulation/targeting in cancer

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Neal Devaraj

UC San Diego
Chemistry and Biochemistry

Devaraj Lab

How can we manipulate lipid signaling processes in artificial and living cells

Kim Dore

Kim Dore

UC San Diego
Neuroscience

Dore Lab

Molecular mechanisms underlying synaptic weakening and resilience in the context of Alzheimer's disease

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Sandra Encalada

Scripps Research Institute

Encalada Lab

Molecular mechanisms of neuronal endolysosomal trafficking in health and in neurodegeneration.

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Dannielle Engle

The Salk Institute

Engle Lab

Therapeutic interception of aberrant glycosylation in pancreatic disease

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Jeff Esko

UC San Diego
Cellular and Molecular Medicine

Esko Lab

Signaling through glycan binding proteins that leads to cancer

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Ronald M. Evans

The Salk Institute
Gene Expression Laboratory

Evans Lab

System approaches to map signaling networks impacting organismal health and disease

Gen-Sheng Feng

Gen-Sheng Feng

UC San Diego
Biological Sciences

Feng Lab

Deciphering the anti-oncogenic effects of oncoproteins in liver cancer

Fleur Ferguson

Fleur Ferguson

UC San Diego
Chemistry and Biochemistry

Ferguson Lab

Chemical biology approaches to interrogating disease signaling in cancer and neurodegeneration

Mark Ginsberg

Mark Ginsberg

UC San Diego
Rheumatology, Allergy & Immunology

Ginsberg Lab

The Ginsberg Lab studies bi-directional transmembrane signaling by integrin adhesion receptors using biochemistry, cell biology, and forward and reverse genetics

David J. Gonzalez

David J. Gonzalez

UC San Diego
Pharmacy and Pharmaceutical Sciences

Gonzalez Lab

Studying bacterial pathogenesis, host responses to infection, and the impact of the microbiome on health and disease

Åsa Gustafsson

Åsa Gustafsson

UC San Diego
Pharmacy and Pharmaceutical Sciences

Gustafsson Lab

Regulation of mitochondrial morphology, function and turnover in cardiac homeostasis and heart failure

Silvio Gutkind

Silvio Gutkind

UC San Diego
Pharmacology

Gutkind Lab

Translating our scientific discoveries into novel precision treatment options and immunotherapies to prevent and treat cancer

Bruce Hamilton

Bruce Hamilton

UC San Diego
Cellular and Molecular Medicine

Hamilton Lab

Genetic architectures that promote robust development in noisy signaling environments

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Tracy Handel

UC San Diego
Pharmacy and Pharmaceutical Sciences

Handel Lab

Structure and signaling mechanisms of G protein-coupled and atypical chemokine receptors

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Matthew Hangauer

UC San Diego
Dermatology

Hangauer Lab

Cancer, mutagenesis, apoptosis, immunotherapy, ferroptosis

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Nan Hao

UC San Diego
Biological Sciences

Hao Lab

Probing and engineering single-cell aging trajectories using systems and synthetic biology approaches

Tom Hnasko

Tom Hnasko

UC San Diego
Neuroscience

Hnasko Lab

Neural circuits & behavior, neurotransmitter co-release, drug addiction, Parkinson’s disease

Vivian Hook

Vivian Hook

UC San Diego
Pharmacy and Pharmaceutical Sciences

Hook Lab

Cell signaling via neurotransmitters, exosomes, and lysosomal leakage in health and neurological diseases

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Enfu Hui

UC San Diego
Biological Sciences

Hui Lab

Mechanistic dissection of immune checkpoint receptors

Tony Hunter

Tony Hunter

The Salk Institute

Hunter Lab

Targeting protein histidine phosphorylation in pancreatic cancer, breast cancer and neuroblastoma

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Tom Huxford

San Diego State University
Chemistry and Biochemistry

Huxford Lab

Structure and mechanism of cellular factors that control transcription factor NF-kappaB activity

Paul Insel

Paul Insel

UC San Diego
Pharmacology

Insel Lab

GPCR signaling, expression and roles in cellular function related to health and disease

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Qingfei Jiang

UC San Diego
Regenerative Medicine

Jiang Lab

Double-stranded RNA induced inflammation signaling in leukemia initiating cells and hematopoietic stem cells by deciphering mechanisms of RNA editing dysregulation in pediatric leukemia

Bill Joiner

Bill Joiner

UC San Diego
Pharmacology

Joiner Lab

Regulation of neurotransmitter signaling and the sleep/wake cycle in health and disease

Michael Karin

Michael Karin

UC San Diego
Pharmacology

Karin Lab

Inflammation and cancer

Randy Kaufman

Randy Kaufman

Sanford Burnham Prebys

Kaufman Lab

The mechanisms by which protein misfolding in the endoplasmic reticulum cause human disease

Irina Kufareva

Irina Kufareva

UC San Diego
Pharmacy and Pharmaceutical Sciences

Kufareva Lab

Computational structural and systems pharmacology of GPCRs

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Uri Manor

UC San Diego

Manor Lab

Cellular and molecular mechanisms underlying organelle dynamics in health and disease

Andy McCammon

Andy McCammon

UC San Diego
Pharmacology

McCammon Lab

Development and application of computational methods to simulate molecular systems involved in signaling

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Hiruy Meharena

UC San Diego
Biological Sciences

Meharena Lab

Developmental and cognitive genomics in neurological disorders

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Andrew Mendiola

UC San Diego
Pharmacology

Mendiola Lab

Decoding mechanisms of brain innate immune cell dysfunction in neurological diseases

Marc Montminy

Marc Montminy

The Salk Institute

Montminy Lab

Transcriptional control of glucose metabolism by phosphorylation-dependent activators

Alysson Muotri

Alysson Muotri

UC San Diego
Pediatrics

Muotri Lab

Brain organogenesis using stem cells and neural signaling during development and evolution

Samuel Myers

Samuel Myers

La Jolla Institute for Immunology

Myers Lab

Signaling pathway crosstalk and post-translational mechanisms controlling cell fate decisions

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Alexandra Newton

UC San Diego
Pharmacology

Newton Lab

Protein phosphorylation and deregulated signaling in cancer and neurodegeneration

Peter Novick

Peter Novick

UC San Diego
Cellular and Molecular Medicine

Novick Lab

The role of Rab GTPase networks in the regulation of vesicular traffic, the structure/inheritance of the endoplasmic reticulum, and the mechanism of ER-phagy

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Chris Obara

UC San Diego

Elena Pasquale

Elena Pasquale

Sanford Burnham Prebys

Pasquale Lab

Eph receptor tyrosine kinase signaling and targeting strategies

Gentry Patrick

Gentry Patrick

UC San Diego
Biological Sciences

Patrick Lab

Glutamate receptor trafficking and turnover at CNS synapses in health and disease

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Gulcin Pekkurnaz

UC San Diego
Biological Sciences

Pekkurnaz Lab

Mechanisms regulating neuronal metabolic homeostasis and mitochondria in health and diseases

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Lorraine Pillus

UC San Diego
Biological Sciences

Pillus Lab

Probing aging and epigenetics through the lenses of metabolism and chromatin biology

Samara Reck-Peterson

Samara Reck-Peterson

UC San Diego
Cellular and Molecular Medicine

Reck-Peterson Lab

Molecular mechanisms of intracellular transport in health and disease

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Ze’ev Ronai

Sanford Burnham Prebys

Ronai Lab

Mapping rewired signaling in cancer

Alan Saghatelian

Alan Saghatelian

The Salk Institute

Saghatelian Lab

Discovery and characterization of biologically active lipids and microproteins in health and disease

Alan Saltiel

Alan Saltiel

UC San Diego
Endocrinology and Metabolism

Saltiel Lab

Molecular mechanisms governing the regulation of metabolism

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Elsa Sanchez Lopez

UC San Diego
Orthopaedic Surgery

Understanding the interface between metabolic adaptation and signal transduction in macrophage immune functions

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David Schlaepfer

UC San Diego
Obstetrics, Gynecology, and Reproductive Sciences

Schlaepfer Lab

Targeting chemtherapy resistance and immune evasion pathways in ovarian cancer.

Johannes Schoeneberg

Johannes Schoeneberg

UC San Diego
Pharmacology

Schoeneberg Lab

4D cell biology using advanced microscopy, stem cells, and machine learning

Julian Schroeder

Julian Schroeder

UC San Diego
Biological Sciences

Schroeder Lab

Molecular mechanisms by which plants respond to and mount resistance to environmental stresses

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Nathan Shaner

UC San Diego
Neuroscience

Shaner Lab

Engineering and applying genetically encoded optical probes and actuators for live cell microscopy

Reuben Shaw

Reuben Shaw

The Salk Institute

Shaw Lab

How cells rewire growth and metabolism in nutrient-deprived conditions

JasonSlicklick

Jason Sicklick

UC San Diego
Surgery

Molecular mechanisms underlying drug sensitivity and resistance in cancer

Christal Sohl

Christal Sohl

San Diego State University
Chemistry and Biochemistry

Sohl Lab

The kinetic, structural, and cellular consequences of enzyme mutations that drive cancer

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Nick Spitzer

UC San Diego
Biological Sciences

Spitzer Lab

Brain plasticity and neurotransmitter switching

Roger Sunahara

Roger Sunahara

UC San Diego
Pharmacology

Sunahara Lab

Understanding the structural and functional basis for hormone and drug modulation of G protein-coupled receptors

Susan Taylor

Susan Taylor

UC San Diego
Pharmacology

Taylor Lab

Structure and function of protein kinases

Christie Towers

Christie Towers

The Salk Institute

Towers Lab

Targeting canonical and non-canonical mechanisms of autophagy and mitophagy in cancer cells

JoAnn Trejo

JoAnn Trejo

UC San Diego
Pharmacology

Trejo Lab

Cell signaling in vascular inflammation and cancer

Elizabeth Villa

Elizabeth Villa

UC San Diego
Biological Sciences

Villa Lab

Development and application of cryo-electron tomography to study various cellular processes including LRRK2 in Parkinson's disease

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Karl Willert

UC San Diego
Cellular and Molecular Medicine

Willert Lab

The role of WNT signaling in development and disease

Tony Yaksh

Tony Yaksh

UC San Diego
Anesthesiology, Pharmacology

Yaksh Lab

Neuraxial cell signaling in pain states secondary to tissue and nerve injury

Jing Yang

Jing Yang

UC San Diego
Pharmacology

Yang Lab

Cell signaling and communication in tumor metastasis

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Peter Zage

UC San Diego
Pediatrics

Zage Lab

Identifying novel therapeutic targets and developing new treatment approaches for pediatric solid tumors

Jin Zhang

Jin Zhang

UC San Diego
Pharmacology

Zhang Lab

Spatiotemporal regulation of cell signaling in health and disease

Huilin Zhou

Huilin Zhou

UC San Diego
Cellular and Molecular Medicine

Zhou Lab

Deciphering signaling mechanisms that prevent chromosomal rearrangements and aneuploidy