
Susan Ackerman
UC San Diego
Biological SciencesMolecular mechanisms underlying neurodegeneration and CNS development

Ludmil Alexandrov
UC San Diego
Cellular and Molecular MedicineUnderstanding the molecular processes that lead to cancer


Joan Heller Brown
UC San Diego
PharmacologyHow G-protein signaling pathways regulate cell growth and inflammation and drive dysfunction in cancer and cardiac disease

Itay Budin
UC San Diego
Chemistry and BiochemistryHow lipids act to shape cells and their membrane-bound signaling networks

Michael Burkart
UC San Diego
Chemistry and BiochemistryDrug discovery and development; RNA processing

Cosimo Commisso
Sanford Burnham Prebys
Signaling pathways that regulate metabolic stress tolerance in cancer

Leslie A. Crews
UC San Diego
Regenerative MedicineCellular and Molecular signaling mechanisms that drive multiple myeloma stem cell activity and disease regeneration

Rich Daneman
UC San Diego
PharmacologyCellular and molecular mechanisms that regulate the blood-brain barrier in health and disease

Ed Dennis
UC San Diego
Pharmacology, Chemistry and BiochemistryMechanism of the Phospholipase A Superfamily in Initiating Lipid Cell Signaling in Inflammation

Arshad Desai
UC San Diego
Biological SciencesMechanisms ensuring accurate genome inheritance during cell division and their dysregulation/targeting in cancer

Neal Devaraj
UC San Diego
Chemistry and BiochemistryHow can we manipulate lipid signaling processes in artificial and living cells

Sandra Encalada
Scripps Research Institute
Molecular mechanisms of neuronal endolysosomal trafficking in health and in neurodegeneration.

Dannielle Engle
The Salk Institute
Therapeutic interception of aberrant glycosylation in pancreatic disease

Ronald M. Evans
The Salk Institute
Gene Expression LaboratorySystem approaches to map signaling networks impacting organismal health and disease

Gen-Sheng Feng
UC San Diego
Biological SciencesDeciphering the anti-oncogenic effects of oncoproteins in liver cancer

Fleur Ferguson
UC San Diego
Chemistry and BiochemistryChemical biology approaches to interrogating disease signaling in cancer and neurodegeneration

Frank Furnari
UC San Diego
Regenerative MedicineDeciphering and targeting signaling networks in the etiology of brain cancer

Mark Ginsberg
UC San Diego
Rheumatology, Allergy & ImmunologyThe Ginsberg Lab studies bi-directional transmembrane signaling by integrin adhesion receptors using biochemistry, cell biology, and forward and reverse genetics

David J. Gonzalez
UC San Diego
Pharmacy and Pharmaceutical SciencesStudying bacterial pathogenesis, host responses to infection, and the impact of the microbiome on health and disease

Åsa Gustafsson
UC San Diego
Pharmacy and Pharmaceutical SciencesRegulation of mitochondrial morphology, function and turnover in cardiac homeostasis and heart failure

Silvio Gutkind
UC San Diego
PharmacologyTranslating our scientific discoveries into novel precision treatment options and immunotherapies to prevent and treat cancer

Bruce Hamilton
UC San Diego
Cellular and Molecular MedicineGenetic architectures that promote robust development in noisy signaling environments

Tracy Handel
UC San Diego
Pharmacy and Pharmaceutical SciencesStructure and signaling mechanisms of G protein-coupled and atypical chemokine receptors

Matthew Hangauer
UC San Diego
DermatologyCancer, mutagenesis, apoptosis, immunotherapy, ferroptosis

Diana Hargreaves
The Salk Institute
Molecular BiologyUnderstanding the role of SWI/SNF chromatin remodeling complexes in cancer and immunity

Svasti Haricharan
San Diego State University
Biological SciencesUnderstanding the somatic molecular biology of cancer through the lens of patient characteristics

Tom Hnasko
UC San Diego
NeuroscienceNeural circuits & behavior, neurotransmitter co-release, drug addiction, Parkinson’s disease

Vivian Hook
UC San Diego
Pharmacy and Pharmaceutical SciencesCell signaling via neurotransmitters, exosomes, and lysosomal leakage in health and neurological diseases

Tony Hunter
The Salk Institute
Targeting protein histidine phosphorylation in pancreatic cancer, breast cancer and neuroblastoma

Tom Huxford
San Diego State University
Chemistry and BiochemistryStructure and mechanism of cellular factors that control transcription factor NF-kappaB activity

Paul Insel
UC San Diego
PharmacologyGPCR signaling, expression and roles in cellular function related to health and disease

Qingfei Jiang
UC San Diego
Regenerative MedicineDouble-stranded RNA induced inflammation signaling in leukemia initiating cells and hematopoietic stem cells by deciphering mechanisms of RNA editing dysregulation in pediatric leukemia

Bill Joiner
UC San Diego
PharmacologyRegulation of neurotransmitter signaling and the sleep/wake cycle in health and disease


Randy Kaufman
Sanford Burnham Prebys
The mechanisms by which protein misfolding in the endoplasmic reticulum cause human disease

Irina Kufareva
UC San Diego
Pharmacy and Pharmaceutical SciencesComputational structural and systems pharmacology of GPCRs

Andrew Lowy
UC San Diego
OncologyIdentifying and targeting signals that drive tumor progression and drug resistance in pancreatic and appendiceal cancers

Andy McCammon
UC San Diego
PharmacologyDevelopment and application of computational methods to simulate molecular systems involved in signaling

Hiruy Meharena
UC San Diego
Biological SciencesDevelopmental and cognitive genomics in neurological disorders

Andrew Mendiola
UC San Diego
PharmacologyDecoding mechanisms of brain innate immune cell dysfunction in neurological diseases

Teresa Monkkonen
San Diego State University
Biological SciencesFunctions of autophagy in the tumor microenvironment and intracellular signaling

Marc Montminy
The Salk Institute
Transcriptional control of glucose metabolism by phosphorylation-dependent activators

Alysson Muotri
UC San Diego
PediatricsBrain organogenesis using stem cells and neural signaling during development and evolution

Samuel Myers
La Jolla Institute for Immunology
Signaling pathway crosstalk and post-translational mechanisms controlling cell fate decisions

Alexandra Newton
UC San Diego
PharmacologyProtein phosphorylation and deregulated signaling in cancer and neurodegeneration

Peter Novick
UC San Diego
Cellular and Molecular MedicineThe role of Rab GTPase networks in the regulation of vesicular traffic, the structure/inheritance of the endoplasmic reticulum, and the mechanism of ER-phagy

Chris Obara
UC San Diego
Directly visualizing individual signaling events with advanced microscopy techniques

Elena Pasquale
Sanford Burnham Prebys
Eph receptor tyrosine kinase signaling and targeting strategies

Gentry Patrick
UC San Diego
Biological SciencesGlutamate receptor trafficking and turnover at CNS synapses in health and disease

Gulcin Pekkurnaz
UC San Diego
Biological SciencesMechanisms regulating neuronal metabolic homeostasis and mitochondria in health and diseases

Lorraine Pillus
UC San Diego
Biological SciencesProbing aging and epigenetics through the lenses of metabolism and chromatin biology

Padmini Rangamani
UC San Diego
Computational systems biology and biophysics to generate predictions about spatio-temporal dynamics of signaling molecules

Samara Reck-Peterson
UC San Diego
Cellular and Molecular MedicineMolecular mechanisms of intracellular transport in health and disease


Alan Saghatelian
The Salk Institute
Discovery and characterization of biologically active lipids and microproteins in health and disease

Alan Saltiel
UC San Diego
Endocrinology and MetabolismMolecular mechanisms governing the regulation of metabolism

Elsa Sanchez Lopez
UC San Diego
Orthopaedic SurgeryUnderstanding the interface between metabolic adaptation and signal transduction in macrophage immune functions

David Schlaepfer
UC San Diego
Obstetrics, Gynecology, and Reproductive SciencesTargeting chemtherapy resistance and immune evasion pathways in ovarian cancer.

Johannes Schoeneberg
UC San Diego
Pharmacology4D cell biology using advanced microscopy, stem cells, and machine learning

Julian Schroeder
UC San Diego
Biological SciencesMolecular mechanisms by which plants respond to and mount resistance to environmental stresses

Nathan Shaner
UC San Diego
NeuroscienceEngineering and applying genetically encoded optical probes and actuators for live cell microscopy

Reuben Shaw
The Salk Institute
How cells rewire growth and metabolism in nutrient-deprived conditions

Jason Sicklick
UC San Diego
SurgeryMolecular mechanisms underlying drug sensitivity and resistance in cancer

Christal Sohl
San Diego State University
Chemistry and BiochemistryThe kinetic, structural, and cellular consequences of enzyme mutations that drive cancer


Roger Sunahara
UC San Diego
PharmacologyUnderstanding the structural and functional basis for hormone and drug modulation of G protein-coupled receptors


Christie Towers
The Salk Institute
Targeting canonical and non-canonical mechanisms of autophagy and mitophagy in cancer cells


Elizabeth Villa
UC San Diego
Biological SciencesDevelopment and application of cryo-electron tomography to study various cellular processes including LRRK2 in Parkinson's disease

Karl Willert
UC San Diego
Cellular and Molecular MedicineThe role of WNT signaling in development and disease

Tony Yaksh
UC San Diego
Anesthesiology, PharmacologyNeuraxial cell signaling in pain states secondary to tissue and nerve injury

Peter Zage
UC San Diego
PediatricsIdentifying novel therapeutic targets and developing new treatment approaches for pediatric solid tumors

Huilin Zhou
UC San Diego
Cellular and Molecular MedicineDeciphering signaling mechanisms that prevent chromosomal rearrangements and aneuploidy